Publications | The Mace Lab

Selected Publications

Complete list in Pubmed here

Martinez AL, Shannon MJ, Eisman SE, Hegewisch-Solloa E, Asif AN, Ebrahim TAM, Mace EM. Quantifying Human Natural Killer Cell Migration by Imaging and Image Analysis. Methods Mol Biol. 2022;2463:129-151. doi: 10.1007/978-1-0716-2160-8_10. PMID: 35344172.

Mace EM. Profiling natural killers in COVID-19. J Allergy Clin Immunol. 2022 Jan 17;149(4):1223–4. doi: 10.1016/j.jaci.2022.01.002. Epub ahead of print. PMID: 35051507; PMCID: PMC8761581.

Reed AE, Mace EM. A WICB 50th Favorite: Rapid lytic granule convergence to the MTOC in natural killer cells is dependent on dynein but not cytolytic commitment. Mol Biol Cell. 2022 Feb 1;33(2):fe2. doi: 10.1091/mbc.E21-04-0218. PMID: 35041469.

Seo S, Mace EM. Diversity of human NK cell developmental pathways defined by single-cell analyses. Curr Opin Immunol. 2021 Nov 30;74:106-111. doi: 10.1016/j.coi.2021.11.001. Epub ahead of print. PMID: 34861544.

Hegewisch-Solloa E, Seo S, Mundy-Bosse BL, Mishra A, Waldman EH, Maurrasse S, Grunstein E, Connors TJ, Freud AG, Mace EM. Differential Integrin Adhesome Expression Defines Human NK Cell Residency and Developmental Stage. J Immunol. 2021 Aug 1;207(3):950-965. doi: 10.4049/jimmunol.2100162. Epub 2021 Jul 19. PMID: 34282002; PMCID: PMC8324558. Featured as a Top Read and on the cover!!

Shannon MJ and Mace EM. Natural Killer Cell Integrins and Their Functions in Tissue Residency. Front. Immunol., 10 March 2021; https://doi.org/10.3389/fimmu.2021.647358

Weisberg SP, Connors TJ, Zhu Y, Baldwin MR, Lin WH, Wontakal S, Szabo PA, Wells SB, Dogra P, Gray J, Idzikowski E, Stelitano D, Bovier FT, Davis-Porada J, Matsumoto R, Poon MML, Chait M, Mathieu C, Horvat B, Decimo D, Hudson KE, Zotti FD, Bitan ZC, La Carpia F, Ferrara SA, Mace EM, Milner JD, Moscona A, Hod E, Porotto M, Farber DL. Distinct antibody responses to SARS-CoV-2 in children and adults across the COVID-19 clinical spectrum. Nat Immunol. 2021 Jan;22(1):25-31. doi: 10.1038/s41590-020-00826-9. Epub 2020 Nov 5. PMID: 33154590.

Patel KR, Rodriguez Benavente MC, Lorenz WW, Mace EM, Barb AW. Fc γ receptor IIIa / CD16a processing correlates with the expression of glycan-related genes in human natural killer cells. J Biol Chem. 2020 Dec 11;296:100183. doi: 10.1074/jbc.RA120.015516. Epub ahead of print. PMID: 33310702; PMCID: PMC7948478.

Shin JH, Moreno-Nieves UY, Zhang LH, Chen C, Dixon AL, Linde MH, Mace EM, Sunwoo JB. AHR Regulates NK Cell Migration via ASB2-Mediated Ubiquitination of Filamin A. Front Immunol. 2021 Feb 24;12:624284. doi: 10.3389/fimmu.2021.624284. PMID: 33717133; PMCID: PMC7943850.

Mace EM, Paust S, Conte MI, Baxley RM, Schmit MM, Patil SL, Guilz NC, Mukherjee M, Pezzi AE, Chmielowiec J, Tatineni S, Chinn IK, Akdemir ZC, Jhangiani SN, Muzny DM, Stray-Pedersen A, Bradley RE, Moody M, Connor PP, Heaps AG, Steward C, Banerjee PP, Gibbs RA, Borowiak M, Lupski JR, Jolles S, Bielinsky AK, Orange JS. Human NK cell deficiency as a result of biallelic mutations in MCM10. J Clin Invest. 2020 Oct 1;130(10):5272-5286. doi: 10.1172/JCI134966. PMID: 32865517; PMCID: PMC7524476.

Gunesch JT, Dixon AL, Ebrahim TA, Berrien-Elliott M, Tatineni S, Kumar T, Hegewisch-Solloa E, Fehniger TA, Mace EM. CD56 regulates human NK cell cytotoxicity through Pyk2. Elife. 2020 Jun 8;9:e57346. doi: 10.7554/eLife.57346. Epub ahead of print. PMID: 32510326.

Cook SA, Comrie WA, Poli MC, Similuk M, Oler AJ, Faruqi AJ, Kuhns DB, Yang S, Vargas-Hernández A, Carisey AF, Fournier B, Anderson DE, Price S, Smelkinson M, Abou Chahla W, Forbes LR, Mace EM, Cao TN, Coban-Akdemir ZH, Jhangiani SN, Muzny DM, Gibbs RA, Lupski JR, Orange JS, Cuvelier GDE, Al Hassani M, Al Kaabi N, Al Yafei Z, Jyonouchi S, Raje N, Caldwell JW, Huang Y, Burkhardt JK, Latour S, Chen B, ElGhazali G, Rao VK, Chinn IK, Lenardo MJ. HEM1 deficiency disrupts mTORC2 and F-actin control in inherited immunodysregulatory disease. Science. 2020 Jul 10;369(6500):202-207. doi: 10.1126/science.aay5663. PMID: 32647003.

Lee BJ, Hegewisch Solloa E, Shannon MJ, Mace EM. Generation of cell-derived matrices that support human NK cell migration and differentiation. J Leukoc Biol. 2020 May 11. doi: 10.1002/JLB.1MA0420-635R. Epub ahead of print. PMID: 32392635.

Lee BJ, Mace EM. From stem cell to immune effector: how adhesion, migration, and polarity shape T-cell and natural killer cell lymphocyte development in vitro and in vivo. Mol Biol Cell. 2020 May 1;31(10):981-991. doi: 10.1091/mbc.E19-08-0424. PMID: 32352896.

Smith SL, Kennedy PR, Stacey KB, Worboys JD, Yarwood A, Seo S, Solloa EH, Mistretta B, Chatterjee SS, Gunaratne P, Allette K, Wang YC, Smith ML, Sebra R, Mace EM, Horowitz A, Thomson W, Martin P, Eyre S, Davis DM. Diversity of peripheral blood human NK cells identified by single-cell RNA sequencing. Blood Adv. 2020 Apr 14;4(7):1388-1406. doi: 10.1182/bloodadvances.2019000699. PMID: 32271902; PMCID: PMC7160259.

Trenton NJ, McLaughlin RT, Bellamkonda SK, Tsao DS, Rodzinski A, Mace EM, Orange JS, Schweikhard V, Diehl MR. Membrane and Actin Tethering Transitions Help IQGAP1 Coordinate GTPase and Lipid Messenger Signaling. Biophys J. 2020 Feb 4;118(3):586-599. doi: 10.1016/j.bpj.2019.12.023. Epub 2019 Dec 31. PMID: 31952801; PMCID: PMC7002982.

Chen L, Youssef Y, Robinson C, Ernst GF, Carson MY, Young KA, Scoville SD, Zhang X, Harris R, Sekhri P, Mansour AG, Chan WK, Nalin AP, Mao HC, Hughes T, Mace EM, Pan Y, Rustagi N, Chatterjee SS, Gunaratne PH, Behbehani GK, Mundy-Bosse BL, Caligiuri MA, Freud AG. CD56 Expression Marks Human Group 2 Innate Lymphoid Cell Divergence from a Shared NK Cell and Group 3 Innate Lymphoid Cell Developmental Pathway. Immunity. 2018 Sep 18;49(3):464-476.e4. doi: 10.1016/j.immuni.2018.08.010. Epub 2018 Sep 4. PubMed PMID: 30193847; PubMed Central PMCID: PMC6148384

Mace EM, Orange JS. Emerging insights into human health and NK cell biology from the study of NK cell deficiencies. Immunol Rev. 2019 Jan;287(1):202-225. doi: 10.1111/imr.12725. PubMed PMID: 30565241; PubMed Central PMCID: PMC6310041.

Orange JS, Mace EM, French AR, Yokoyama WM, Fehniger TA, Cooper MA. Comment on: Evidence of innate lymphoid cell redundancy in humans. Nat Immunol. 2018 Aug;19(8):788-789. doi: 10.1038/s41590-018-0164-5. PubMed PMID: 30026477.

Gunesch JT, Angelo LS, Mahapatra S, Deering RP, Kowalko JE, Sleiman P, Tobias JW, Monaco-Shawver L, Orange JS, Mace EM. Genome-wide analyses and functional profiling of human NK cell lines. Mol Immunol. 2018 Jul 24. pii: S0161-5890(18)30556-X. doi: 10.1016/j.molimm.2018.07.015. [Epub ahead of print] PubMed PMID: 30054012.

Mace EM. Phosphoinositide-3-kinase signaling in human natural killer cells: new insights from primary immunodeficiency. Front Immunol. 2018 Mar 7;9:445. doi:10.3389/fimmu.2018.00445. 2018.

Ruiz-García R, Vargas-Hernandez A, Chinn IK, Angelo LS, Cao TN, Coban-Akdemir Z, Jhangiani SN, Meng Q, Forbes LR, Muzny DM, Allende LM, Ehlayel MS, Gibbs RA, Lupski JR, Uzel G, Orange JS, Mace EM. Mutations in PI3K110δ cause impaired NK cell function partially rescued by rapamycin treatment. J Allergy Clin Immunol. 2018 Jan 9. pii: S0091-6749(18)30026-5. doi: 10.1016/j.jaci.2017.11.042. [Epub ahead of print] PubMed PMID: 29330011.

Lee BJ and Mace EM, 2017. Acquisition of cell migration defines NK cell differentiation from hematopoietic stem cell precursors. Mol Biol Cell. 2017 Oct 11. pii: mbc.E17-08-0508. doi: 10.1091/mbc.E17-08-0508. [Epub ahead of print]

Mace EM, Bigley V, Gunesch JT, Chinn IK, Angelo LS, Care MA, Maisuria S, Keller MD, Togi S, Watkin LB, LaRosa DF, Jhangiani SN, Muzny DM, Stray-Pedersen A, Coban Akdemir Z, Smith JB, Hernández-Sanabria M, Le DT, Hogg GD, Cao TN, Freud AG, Szymanski EP, Savic S, Collin M, Cant AJ, Gibbs RA, Holland SM, Caligiuri MA, Ozato K, Paust S, Doody GM, Lupski JR, Orange JS. Biallelic mutations in IRF8 impair human NK cell maturation and function. J Clin Invest. 2016 Nov 28. pii: 86276. doi: 10.1172/JCI86276

Mace EM, Gunesch JT, Dixon AL, Orange JS. Human NK cell development requires CD56-mediated motility and formation of the developmental synapse. Nat. Commun. 7:12171 doi: 10.1038/ncomms12171 (2016).

Viswanath DI*, Mace EM*, Hsu HT, Orange JS. Quantification of natural killer cell polarization and visualization of synaptic granule externalization by imaging flow cytometry. Clin Immunol. 2016 Mar 3. pii: S1521-6616(16)30031-6. doi: 10.1016/j.clim.2016.03.004. [Epub ahead of print] PMID: 26948929 *Co-first authors. PMID: 26948929

Spinner MA, Ker JP, Stoudenmire CJ, Fadare O, Mace EM, Orange JS, Hsu AP, Holland SM. GATA2 deficiency underlying severe blastomycosis and fatal herpes simplex virus-associated hemophagocytic lymphohistiocytosis. J Allergy Clin Immunol. 2016 Feb;137(2):638-40. doi: 10.1016/j.jaci.2015.07.043. Epub 2015 Sep 26. No abstract available. PMID: 26395816

Mace EM, Orange JS. Insights into primary immune deficiency from quantitative microscopy. J Allergy Clin Immunol. 2015 Jun 13. [Epub ahead of print] Review. PMID: 26078103

Angelo LS, Banerjee PP, Monaco-Shawver L, Rosen JB, Makedonas G, Forbes LR,Mace EM, Orange JS. Practical NK cell phenotyping and variability in healthy adults. Immunol Res. 2015 Jul;62(3):341-56. PMID: 26013798

Watkin LB, Jessen B, Wiszniewski W, Vece TJ, Jan M, Sha Y, Thamsen M, Santos-Cortez RL, Lee K, Gambin T, Forbes LR, Law CS, Stray-Pedersen A, Cheng MH,Mace EM, Anderson MS, Liu D, Tang LF, Nicholas SK, Nahmod K, Makedonas G, Canter DL, Kwok PY, Hicks J, Jones KD, Penney S, Jhangiani SN, Rosenblum MD, Dell SD, Waterfield MR, Papa FR, Muzny DM, Zaitlen N, Leal SM, Gonzaga-Jauregui C; Baylor-Hopkins Center for Mendelian Genomics, Boerwinkle E, Eissa NT, Gibbs RA, Lupski JR, Orange JS, Shum AK. COPA mutations impair ER-Golgi transport and cause hereditary autoimmune-mediated lung disease and arthritis. Nat Genet. 2015 Jun;47(6):654-60. PMID: 25894502

Mace EM, Orange JS. Lytic immune synapse function requires filamentous actin deconstruction by Coronin 1A.Proceedings of the National Academy of Sciences USA. 2014 Apr 23 (Epub).PMID: 24760828

Mace EM, Orange JS. Visualization of the immunological synapse by dual color time-gated stimulated emission depletion (STED) nanoscopy. J of Vis Exp. 2014 Mar 24;(85) PMID: 24686478

Mace EM, Dongre P, Sinha P, Hsu HT, Watkins LB, Forbes LR, and Orange JS. Cell biological steps and checkpoints in accessing NK cell cytotoxicity. Immunol Cell Biol. 2014 Mar;92(3). PMID: 24445602

Spinner MA, Sanchez LA, Hsu AP, Shaw PA, Zerbe CS, Calvo KR, Arthur DC, Gu W, Gould CM, Brewer CC, Cowen EW, Freeman AF, Olivier KN, Uzel G, Zelazny AM, Daub JR, Spalding CD, Claypool RJ, Giri NK, Alter BP, Mace EM, Orange JS, Cuellar-Rodriguez J, Hickstein DD, Holland SM. GATA2 deficiency: a protean disorder of hematopoiesis, lymphatics, and immunity. Blood. 2014 Feb 6;123(6):809-21. Epub 2013 Nov 13. PMID: 24227816

Mace EM, Hsu AP, Monaco-Shawver L, Makedonas G, Rosen JB, Dropulic L, Cohen JI, Frenkel EP, Bagwell JC, Sullivan JL, Biron CA, Spalding C, Zerbe CS, Uzel G, Holland SM, Orange JS. Mutations in GATA2 cause human NK cell deficiency with specific loss of the CD56bright subset*. Blood. 2013 Apr 4;121(14). PMID: 23365458

Mace EM, Orange JS. New views of the human NK cell immunological synapse: recent advances enabled by super- and high-resolution imaging techniques.Front Immunol. 2012;3:421. PMID: 23316204

Mace EM and Orange JS. Dual channel STED nanoscopy of lytic granules on actin filaments in natural killer cells.Commun Integr Biol. 2012 Mar 1;5(2):184-6. PMID: 22808328